Description

Benzenemethanamine, α-Methyl-2,4,6-Tris(1-Methylethyl)-, (αr)- is a chiral amine derivative featuring a sterically hindered, triisopropyl-substituted benzene core. This compound matters as a sophisticated chiral building block and ligand precursor for asymmetric synthesis, offering unique steric and electronic properties to direct reaction pathways. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Chiral Ligand in Asymmetric Catalysis: Serves as a precursor for the synthesis of novel ligands used in enantioselective hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.
• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Organocatalyst Development: Utilized as a core structure for developing new organocatalysts due to its bulky, defined stereochemistry which can influence substrate approach.
• Advanced Material Synthesis: Employed in the creation of specialty polymers, liquid crystals, or molecular receptors where precise spatial arrangement is critical.
• Agrochemical Research: Used in the synthesis of novel, chiral agrochemicals such as herbicides and fungicides to enhance efficacy and environmental profile.
• Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	Benzenemethanamine, α-Methyl-2,4,6-Tris(1-Methylethyl)-, (αr)-
CAS No.	926622-52-8
Molecular Formula	C19H33N
Molecular Weight	275.47 g/mol
Synonyms	(R)-α-Methyl-2,4,6-triisopropylbenzylamine; (R)-1-(2,4,6-Triisopropylphenyl)ethan-1-amine; (R)-Methyl(2,4,6-triisopropylphenyl)methanamine; (R)-TIPP-Methylamine; Chiral Triisopropylbenzylamine Derivative; (Ar)-α-Methyl-2,4,6-Triisopropylbenzenemethanamine; (R)-1-Aminoethyl-2,4,6-triisopropylbenzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, GC, and NMR to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a cGMP-compliant quality management system for products intended for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.