Description

4'-tert-Butyl-3-Fluoro-1,1'-Biphenyl-4-Carboxylic Acid is a high-purity biphenyl carboxylic acid derivative, distinguished by its tert-butyl and fluorine substituents which impart unique steric and electronic properties. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis, enabling the development of novel active ingredients. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Liquid Crystal Material Precursor: Used in the development of advanced liquid crystal mixtures for display technologies, leveraging its rigid biphenyl core and tailored substituents.
• Agrochemical Synthesis: Serves as a building block for novel herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a starting material for electron-transport or host materials in OLED devices due to its conjugated system.
• Ligand Synthesis for Catalysis: The carboxylic acid functionality allows for derivatization into specialized ligands for transition metal-catalyzed cross-coupling reactions.
• Polymer Modification: Incorporated as a monomer or additive to impart specific thermal stability or solubility characteristics to high-performance polymers.

Basic Information

Product Name	4'-tert-Butyl-3-Fluoro-1,1'-Biphenyl-4-Carboxylic Acid
CAS No.	926236-47-7
Molecular Formula	C₁₇H₁₇FO₂
Molecular Weight	272.32 g/mol
Synonyms	3-Fluoro-4'-(tert-butyl)biphenyl-4-carboxylic acid; 4'-(tert-Butyl)-3-fluoro[1,1'-biphenyl]-4-carboxylic acid; 4'-tert-Butyl-3-fluorobiphenyl-4-carboxylic acid; 3-Fluoro-4'-(1,1-dimethylethyl)-1,1'-biphenyl-4-carboxylic acid; [1,1'-Biphenyl]-4-carboxylic acid, 3-fluoro-4'-(1,1-dimethylethyl)-; 4'-tert-Butyl-3-fluoro-4-biphenylcarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4'-tert-Butyl-3-Fluoro-1,1'-Biphenyl-4-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.