Description

2-(3,3,3-Trifluoropropanamido)Acetic Acid is a high-value fluorinated building block, crucial for introducing the trifluoromethyl group into complex molecular architectures. Its primary value lies in enabling the synthesis of novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology, CNS, and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy.
• Material Science: Serves as a precursor for specialty polymers, coatings, and liquid crystals that require fluorine incorporation for specific performance properties.
• Chemical Research: A versatile reagent in organic synthesis and medicinal chemistry for creating novel fluorinated compounds and exploring structure-activity relationships.
• Peptide Modification: Used to incorporate fluorinated moieties into peptides and peptidomimetics to alter their biological activity and stability.

Basic Information

Product Name	2-(3,3,3-Trifluoropropanamido)Acetic Acid
CAS No.	923972-81-0
Molecular Formula	C5H6F3NO3
Molecular Weight	185.10 g/mol
Synonyms	N-(Carboxymethyl)-3,3,3-trifluoropropanamide; 2-[[(3,3,3-Trifluoropropanoyl)amino]acetic acid; Acetic acid, 2-[(3,3,3-trifluoro-1-oxopropyl)amino]-; Glycine, N-(3,3,3-trifluoropropanoyl)-; 3,3,3-Trifluoropropionylglycine; TFPA-Glycine; Trifluoropropionamidoacetic Acid
EINECS	Contact for details

Quality Control

Our 2-(3,3,3-Trifluoropropanamido)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.