Description

trans-4-Fluoro-Cyclohexylamine is a versatile fluorinated cyclohexylamine derivative, characterized by its trans-configuration and a fluorine substituent at the 4-position. This specific stereochemistry and functional group combination make it a valuable chiral building block for the synthesis of complex molecules, offering enhanced metabolic stability and bioavailability. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom improves biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials with tailored properties.
• Chemical Biology Probes: Utilized as a building block for fluorinated probes and tags in biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific stereochemistry and fluorination.

Basic Information

Product Name	trans-4-Fluoro-Cyclohexylamine
CAS No.	923672-47-3
Molecular Formula	C6H12FN
Molecular Weight	117.16 g/mol
Synonyms	trans-4-Fluorocyclohexanamine; (1r,4r)-4-Fluorocyclohexanamine; 4-Fluorocyclohexylamine (trans); trans-4-Fluoro-1-cyclohexylamine; 4-Fluoro-trans-cyclohexylamine; 4-Fluoro-cyclohexylamine (trans); 923672-47-3; (trans)-4-Fluorocyclohexylamine
EINECS	Contact for details

Quality Control

Our trans-4-Fluoro-Cyclohexylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. The compound is hygroscopic; handle under inert atmosphere for long-term storage to maintain quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.