Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethoxy)Benzaldehyde is a high-purity, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is valued for its unique molecular structure, which incorporates both a pinacol boronate ester and a trifluoromethoxy-substituted benzaldehyde, making it a versatile reagent for cross-coupling reactions. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group serves as a crucial coupling partner for the formation of carbon-carbon bonds, enabling the construction of complex biaryl structures common in modern drug candidates.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or molecular components for organic semiconductors.
• Chemical Biology & Proteomics: Acts as a valuable probe or linker in the development of chemical tools for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific custom synthesis projects.

Basic Information

Item	Detail
Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethoxy)Benzaldehyde
CAS No.	923281-74-7
Molecular Formula	C14H16BF3O4
Molecular Weight	316.08 g/mol
Synonyms	2-(Trifluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; [5-Formyl-2-(trifluoromethoxy)phenyl]boronic acid pinacol ester; 2-(Trifluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarbaldehyde; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)benzaldehyde; Pinacol [5-Formyl-2-(trifluoromethoxy)phenyl]boronate
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethoxy)Benzaldehyde is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request. We are committed to meeting the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.