Description

1,2,3,4-Tetrahydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline is a versatile and high-value organoboron building block, essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic structures.
• Material Science: Serves as a monomer or functionalization agent in the creation of organic semiconductors, OLED materials, and conductive polymers.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery of new drug candidates through high-throughput screening and library synthesis.
• Academic & Industrial R&D: A fundamental reagent for methodological development in cross-coupling and other transition metal-catalyzed reactions.
• Ligand Synthesis: Used to prepare sophisticated chiral or bidentate ligands for asymmetric catalysis.

Basic Information

Product Name	1,2,3,4-Tetrahydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline
CAS No.	922718-55-6
Molecular Formula	C₁₅H₂₂BNO₂
Molecular Weight	259.15 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline; 6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline; THIQ-BPin; 6-BPin-tetrahydroisoquinoline; 1,2,3,4-Tetrahydroisoquinoline-6-boronic acid pinacol ester; Isoquinoline-6-boronic acid, 1,2,3,4-tetrahydro-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1,2,3,4-Tetrahydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) confirming identity, purity (typically >97% by HPLC), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.