Description

1-(Difluoromethoxy)-2-Iodobenzene is a specialized fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a difluoromethoxy ether and an iodine substituent, makes it a valuable precursor for constructing complex molecules via cross-coupling reactions. This high-purity intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the difluoromethoxy and iodine groups contribute to biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form new carbon-carbon bonds.
• Ligand Synthesis: Utilized in the preparation of complex ligands for catalysis and coordination chemistry.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine substitution and developing new fluorination methodologies.

Basic Information

Product Name	1-(Difluoromethoxy)-2-Iodobenzene
CAS No.	920981-12-0
Molecular Formula	C7H5F2IO
Molecular Weight	269.02 g/mol
Synonyms	2-Iodo-1-(difluoromethoxy)benzene; o-Iodo(difluoromethoxy)benzene; 1-Iodo-2-(difluoromethoxy)benzene; Benzene, 1-(difluoromethoxy)-2-iodo-; Difluoromethoxy-2-iodobenzene; 2-Iodophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-2-Iodobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to confirm identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and transfers should be minimized under direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.