Description

1-(Difluoromethoxy)Naphthalene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy substituent on the naphthalene core makes it a valuable intermediate for introducing fluorine-containing motifs, which are critical for modulating the physicochemical properties of target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a key precursor in the development of novel active ingredients. The CAS number for this compound is 920981-10-8.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for introducing the difluoromethoxy pharmacophore to enhance metabolic stability and membrane permeability.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, where the fluorine atoms can improve biological activity and environmental persistence.
• Material Science: Serves as a monomer or precursor for synthesizing specialty polymers and liquid crystals with tailored electronic and optical properties.
• Organic Synthesis: A versatile reagent for constructing complex polycyclic aromatic structures via cross-coupling reactions and other metal-catalyzed transformations.
• Fluorine Chemistry Research: An important substrate for studying new fluorination methodologies and the behavior of fluorinated aromatic systems.

Basic Information

Product Name	1-(Difluoromethoxy)Naphthalene
CAS No.	920981-10-8
Molecular Formula	C₁₁H₈F₂O
Molecular Weight	194.18 g/mol
Synonyms	1-(Difluoromethoxy)naphthalene; Naphthalene, 1-(difluoromethoxy)-; 1-Naphthyl Difluoromethyl Ether; α-Naphthyl Difluoromethyl Ether; 1-(Difluoromethoxy)naphthalene; Difluoromethoxy Naphthalene; 920981-10-8
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)Naphthalene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.