Description

8-(Trifluoromethyl) Quinolin-2(1H)-One is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters because the trifluoromethyl group imparts unique physicochemical properties, such as enhanced metabolic stability and lipophilicity, which are critical in modern material and pharmaceutical design. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries seeking to incorporate fluorine into novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the CF3 group improves biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functionalized organic molecules used in organic light-emitting diodes (OLEDs) and liquid crystal displays (LCDs).
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: An important substrate for investigating new fluorination reactions and studying structure-activity relationships (SAR).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client-specific projects.

Basic Information

Product Name	8-(Trifluoromethyl) Quinolin-2(1H)-One
CAS No.	920494-30-0
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	8-(Trifluoromethyl)-1,2-dihydroquinolin-2-one; 8-(Trifluoromethyl)-2(1H)-quinolinone; 2-Hydroxy-8-(trifluoromethyl)quinoline; 8-Trifluoromethylquinolin-2-ol; 1,2-Dihydro-8-(trifluoromethyl)quinolin-2-one; 8-CF3-Quinolin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethyl) Quinolin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.