Description

3-Chloro-4-Hydroxy-5-Methoxyphenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides with specific activity profiles.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers for OLEDs and semiconductors.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Fine Chemical Manufacturing: An important reagent for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds.

Basic Information

Product Name	3-Chloro-4-Hydroxy-5-Methoxyphenylboronic Acid, Pinacol Ester
CAS No.	919496-57-4
Molecular Formula	C₁₃H₁₈BClO₄
Molecular Weight	284.54 g/mol
Synonyms	(3-Chloro-4-hydroxy-5-methoxyphenyl)boronic acid pinacol ester; 2-(3-Chloro-4-hydroxy-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-hydroxy-5-methoxybenzeneboronic acid pinacol ester; Pinacol (3-chloro-4-hydroxy-5-methoxyphenyl)boronate; Boronic acid, B-(3-chloro-4-hydroxy-5-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI); CAS 919496-57-4
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Hydroxy-5-Methoxyphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.