Description

3-Pyridinemethanamine, n-(2-Methylpropyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional boronic ester derivative. This compound serves as a critical synthetic intermediate in modern organic and medicinal chemistry, enabling the construction of complex molecular architectures. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require specific pyridine-boronate motifs for enhanced activity.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and charge-transport materials.
• Chemical Biology Probe: Serves as a versatile handle for bioconjugation and the development of chemical probes for target identification and validation.
• Catalyst Ligand Synthesis: Acts as a precursor for creating sophisticated nitrogen-containing ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	3-Pyridinemethanamine, n-(2-Methylpropyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	919347-20-9
Molecular Formula	C16H27BN2O2
Molecular Weight	290.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isobutylnicotinamide (common misnomer); N-Isobutyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxamide; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-methylpropyl)nicotinamide; 3-Pyridinecarboxamide, N-(2-methylpropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[5-[[(2-methylpropyl)amino]carbonyl]-3-pyridinyl]-, 1,3-propanediol cyclic ester; 919347-20-9; Isobutyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide
EINECS	Contact for details

Quality Control

Our production of 3-Pyridinemethanamine, n-(2-Methylpropyl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent in-process controls and final release testing. Every batch is analyzed to ensure high chemical purity and structural integrity, critical for sensitive cross-coupling reactions. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential decomposition. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.