Description

4-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Morpholine is a high-value boronic ester derivative and a key pharmaceutical intermediate designed for advanced synthesis. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to accelerate the discovery and production of novel active compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex heterocyclic systems.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of carbon-carbon bonds between the pyridinyl-boronate moiety and various aryl/heteroaryl halides under palladium catalysis.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific biaryl motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic semiconductors, where precise molecular architecture is crucial.
• Ligand and Catalyst Development: The morpholine and pyridine functionalities make it a potential starting point for designing novel chelating ligands and organocatalysts.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	4-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Morpholine
CAS No.	919347-16-3
Molecular Formula	C16H25BN2O3
Molecular Weight	304.20 g/mol
Synonyms	3-((Morpholin-4-yl)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-((5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methyl)morpholine; 5-(Morpholinomethyl)pyridine-3-boronic acid pinacol ester; (5-((Morpholin-4-yl)methyl)pyridin-3-yl)boronic acid pinacol ester; 919347-16-3; 4-[(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methyl]morpholine
EINECS	Contact for details

Quality Control

Our production of 4-((5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methyl)Morpholine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.