Description

Dimethyl-{3-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yloxy]-Propyl}-Amine is a high-value, functionalized pyridine-boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling building block. Its molecular architecture, featuring a protected boronate ester and a tertiary amine linker, makes it indispensable for the efficient synthesis of complex bioactive molecules. This compound is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for constructing novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides, crucial for constructing complex biaryl structures in medicinal chemistry.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying biological pathways and protein function.
• Material Science Research: Serves as a monomer or functional unit in the synthesis of novel organic electronic materials and polymers.
• Agrochemical Intermediate: Potential use in the synthesis of advanced, high-performance crop protection agents.

Basic Information

Item	Details
Product Name	Dimethyl-{3-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yloxy]-Propyl}-Amine
CAS No.	918643-56-8
Molecular Formula	C16H27BN2O3
Molecular Weight	306.21 g/mol
Synonyms	2-[[3-(Dimethylamino)propoxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[3-(dimethylamino)propoxy]pyridine; N,N-Dimethyl-3-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)oxy)propan-1-amine; Boronic acid, B-[6-[3-(dimethylamino)propoxy]-2-pyridinyl]-, pinacol ester; CAS 918643-56-8
EINECS	Contact for details

Quality Control

Our production of Dimethyl-{3-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yloxy]-Propyl}-Amine adheres to stringent GMP-like guidelines to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support custom synthesis and can tailor specifications, including chiral purity if required, to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when appropriate to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.