Description

1-Benzyloxy-2-Chloro-4-Fluorobenzene is a high-purity fluorinated aromatic ether building block of significant importance in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine and chlorine substituents is critical for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and supramolecular structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated aromatic motifs.

Basic Information

Product Name	1-Benzyloxy-2-Chloro-4-Fluorobenzene
CAS No.	918524-11-5
Molecular Formula	C₁₃H₁₀ClFO
Molecular Weight	236.67 g/mol
Synonyms	2-Chloro-4-fluorophenyl benzyl ether; Benzyl 2-chloro-4-fluorophenyl ether; 1-Chloro-2-(benzyloxy)-4-fluorobenzene; 2-Chloro-1-fluoro-4-(phenylmethoxy)benzene; 4-Fluoro-2-chlorophenyl benzyl ether; (2-Chloro-4-fluorophenoxy)methyl]benzene; BCFB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-Benzyloxy-2-Chloro-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.