Description

4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid is a high-value boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials synthesis. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require precise and reliable building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific chlorinated benzoic acid motifs.
• Material Science & OLED Development: A precursor for creating organic light-emitting diode (OLED) materials and other functional polymers where its boronate ester group facilitates precise molecular assembly.
• Ligand & Catalyst Design: Employed in the development of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology & Proteomics: Useful as a probe or linker in bioconjugation chemistry and for the study of biological pathways.
• Academic & Contract Research: A versatile reagent for methodological development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid
CAS No.	918331-73-4
Molecular Formula	C13H16BClO4
Molecular Weight	282.53 g/mol
Synonyms	4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; (4-Chloro-3-carboxyphenyl)boronic acid pinacol ester; 3-Borono-4-chlorobenzoic acid, pinacol ester; 4-Chloro-3-(pinacolatoboryl)benzoic acid; Benzoic acid, 4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 918331-73-4; Pinacol (4-chloro-3-carboxyphenyl)boronate
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.