Description

Cyclopropanecarbonitrile, 1-[3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]- is a high-value boronic ester derivative, a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing cyclopropane and fluorinated aromatic motifs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides requiring specific fluorinated and boronic ester functionalities.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for diagnostic and research applications.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the substituted cyclopropylphenyl moiety into complex molecular architectures.
• Library Synthesis for Drug Discovery: A valuable reagent for medicinal chemists in generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	Cyclopropanecarbonitrile, 1-[3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
CAS No.	917397-94-5
Molecular Formula	C16H19BFNO2
Molecular Weight	287.14 g/mol
Synonyms	1-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarbonitrile; 2-(4-(1-Cyanocyclopropyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-[3-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]cyclopropanecarbonitrile; 1-(3-Fluoro-4-(pinacolatoboron)phenyl)cyclopropanecarbonitrile; 1-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarbonitrile; 1-(3-Fluoro-4-(pinacolato)phenyl)cyclopropanecarbonitrile; 1-(3-Fluoro-4-(pinacolatoboron)phenyl)cyclopropane-1-carbonitrile
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonitrile, 1-[3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for demanding synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.