Description

(S)-Ethyl 3-Methyl-2-((R)-5-(Perfluorophenyl)-3-p-Tolyl-1,2,4-Oxadiazol-4(5H)-Yl)Butanoate is a high-value, chiral fluorinated oxadiazole derivative that serves as a critical synthetic intermediate. Its unique structure, featuring a perfluorinated aromatic ring and a stereodefined ester group, makes it indispensable for constructing complex molecules with specific spatial and electronic properties. This compound is primarily sought after by research and development teams in the pharmaceutical and advanced agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral drug candidates, particularly in antiviral, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and fluorinated materials with unique surface properties.
• Ligand Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis, crucial for efficient and selective chemical manufacturing.
• Chemical Biology Probe: Utilized in academic and industrial research to study enzyme interactions and biological pathways due to its fluorinated tag and defined stereochemistry.

Basic Information

Product Name	(S)-Ethyl 3-Methyl-2-((R)-5-(Perfluorophenyl)-3-p-Tolyl-1,2,4-Oxadiazol-4(5H)-Yl)Butanoate
CAS No.	916676-22-7
Molecular Formula	C22H19F5N2O3
Molecular Weight	454.39 g/mol
Synonyms	Ethyl (2S)-3-methyl-2-[(4R)-5-(pentafluorophenyl)-3-(4-methylphenyl)-1,2,4-oxadiazol-4-yl]butanoate; (S)-Ethyl 3-Methyl-2-((R)-5-(Perfluorophenyl)-3-p-Tolyl-1,2,4-Oxadiazol-4(5H)-Yl)Butyrate; Fluorinated Oxadiazole Ester; CAS 916676-22-7; 1,2,4-Oxadiazole, 4-[(1S)-1-(ethoxycarbonyl)-2-methylpropyl]-5-(pentafluorophenyl)-3-(4-methylphenyl)-, (4R)-; (4R)-4-[(1S)-1-(Ethoxycarbonyl)-2-methylpropyl]-5-(pentafluorophenyl)-3-(4-methylphenyl)-1,2,4-oxadiazole
EINECS	Contact for details

Quality Control

Every batch of (S)-Ethyl 3-Methyl-2-((R)-5-(Perfluorophenyl)-3-p-Tolyl-1,2,4-Oxadiazol-4(5H)-Yl)Butanoate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and chiral integrity. Our products are supported by a detailed Certificate of Analysis (COA) that includes chiral HPLC purity, NMR, and mass spectrometry data. We adhere to cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its highly volatile nature, ensure containers are securely sealed. Keep away from strong bases and fluorides. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.