Description

Methyl-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Carbamic Acid tert-Butyl Ester is a high-purity, protected boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Drug Discovery & Medicinal Chemistry: Used extensively in high-throughput screening and library synthesis for creating novel bioactive compounds.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, and insecticides that require aryl-boronate intermediates.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Utilized for bioconjugation and labeling strategies due to its reactive boronate handle.
• Custom Synthesis & Contract Manufacturing: A vital raw material for CROs and CDMOs producing bespoke organic compounds for client projects.

Basic Information

Item	Details
Product Name	Methyl-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Carbamic Acid tert-Butyl Ester
CAS No.	916587-44-5
Molecular Formula	C18H28BNO4
Molecular Weight	333.24 g/mol
Synonyms	N-Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylaniline; tert-Butyl [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl](methyl)carbamate; 4-(N-Boc-N-methylamino)phenylboronic acid pinacol ester; 4-(N-Methyl-N-Boc-amino)phenylboronic acid pinacol ester; 4-(tert-Butoxycarbonyl(methyl)amino)phenylboronic acid pinacol ester; Boc-4-borono-N-methylaniline pinacol ester; 916587-44-5
EINECS	Contact for details

Quality Control

Our production of Methyl-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenyl]-Carbamic Acid tert-Butyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.