Description

5-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-1-Methyl-1H-Indole, 5,5-Dimethyl-2-(1-Methyl-1H-Indol-5-Yl)-1,3,2-Dioxaborinane is a high-purity, advanced pharmaceutical intermediate belonging to the class of indole-based boronic esters. This compound is a critical building block in modern synthetic organic chemistry, enabling the formation of carbon-carbon bonds via the Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile organoboron reagent for constructing biaryl and heterobiaryl structures in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of new pesticides and herbicides with novel modes of action.
• Material Science: Employed in the synthesis of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology: Acts as a probe or building block for creating molecules used in biochemical assays and proteomics.
• Academic & Contract Research: Essential for methodological development and complex molecule synthesis in university and CRO laboratories.

Basic Information

Product Name	5-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-1-Methyl-1H-Indole, 5,5-Dimethyl-2-(1-Methyl-1H-Indol-5-Yl)-1,3,2-Dioxaborinane
CAS No.	916518-57-5
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (common misassignment); 5,5-Dimethyl-2-(1-methyl-1H-indol-5-yl)-1,3,2-dioxaborinane; 1-Methyl-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1H-indole; 1-Methyl-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)indole; Indole-5-boronic acid, 1-methyl-, 5,5-dimethyl-1,3,2-dioxaborinane ester; 916518-57-5; CAS 916518-57-5
EINECS	Contact for details

Quality Control

Our 5-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)-1-Methyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and potential degradation, ensuring long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.