Description

3-[5-Chloro-2-(Trifluoromethyl)Phenyl]Propionic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because its unique structure, featuring both chloro and trifluoromethyl substituents, enables the precise modulation of physicochemical properties in target molecules, enhancing lipophilicity and metabolic stability. It is primarily needed by pharmaceutical and agrochemical R&D teams for developing novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for anti-inflammatory and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in constructing advanced herbicide and fungicide molecules, where the trifluoromethyl group is prized for its bioactivity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated components for high-performance liquid crystal displays (LCDs).
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials.
• Chemical Research: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) influenced by fluorine atoms.

Basic Information

Product Name	3-[5-Chloro-2-(Trifluoromethyl)Phenyl]Propionic Acid
CAS No.	916420-80-9
Molecular Formula	C10H8ClF3O2
Molecular Weight	252.62 g/mol
Synonyms	5-Chloro-α,α,α-trifluoro-o-tolylpropionic Acid; 3-(5-Chloro-2-(trifluoromethyl)phenyl)propanoic Acid; 2-(Trifluoromethyl)-5-chlorohydrocinnamic Acid; 5-Chloro-2-(trifluoromethyl)hydrocinnamic Acid; 3-(5-Chloro-2-(trifluoromethyl)phenyl)propionic Acid; 916420-80-9; 3-(5-Chloro-2-(trifluoromethyl)phenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our 3-[5-Chloro-2-(Trifluoromethyl)Phenyl]Propionic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.