Description

(Z)-2-Bromo-2-Butenoic Acid is a halogenated unsaturated carboxylic acid that serves as a versatile chiral building block in advanced organic synthesis. Its value lies in the strategic placement of the bromine and carboxylic acid groups on the alkene, enabling precise stereoselective transformations. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other small-molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Monomer: Can be polymerized or incorporated into polymers to create functional materials with specific chemical handles for further modification.
• Organic Synthesis Building Block: Employed in various name reactions (e.g., Heck coupling, conjugate additions) to introduce the (Z)-configured alkene moiety into target molecules.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	(Z)-2-Bromo-2-Butenoic Acid
CAS No.	5405-34-5
Molecular Formula	C4H5BrO2
Molecular Weight	165.00 g/mol
Synonyms	(Z)-2-Bromo-2-butenoic acid; (Z)-α-Bromocrotonic Acid; (2Z)-2-Bromo-2-butenoic acid; (Z)-2-Bromobut-2-enoic Acid; trans-2-Bromo-2-butenoic Acid; (Z)-2-Bromocrotonic Acid; 2-Bromo-(Z)-2-butenoic Acid; Bromocrotonic Acid (Z-isomer)
EINECS	226-477-5

Quality Control

Our (Z)-2-Bromo-2-Butenoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for production and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its nature as a strong acid/organic solvent, store separately from bases, oxidizing agents, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isomeric Purity (Z-isomer, GC/HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.