Description

3-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Propionic Acid is a high-value fluorinated aromatic building block, distinguished by its unique trifluoromethyl and fluorine substituents which impart significant lipophilicity and metabolic stability. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its structure is leveraged to fine-tune biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving thermal stability and optical properties.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, low surface energy, and improved durability.
• Chemical Research & Development: A versatile building block in medicinal chemistry and material science for structure-activity relationship (SAR) studies and novel compound library synthesis.

Basic Information

Product Name	3-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Propionic Acid
CAS No.	916420-41-2
Molecular Formula	C10H6F4O2
Molecular Weight	234.15 g/mol
Synonyms	3-(3-Fluoro-5-(trifluoromethyl)phenyl)propanoic acid; 3-Fluoro-5-(trifluoromethyl)benzenepropanoic Acid; β-(3-Fluoro-5-trifluoromethylphenyl)propionic Acid; 916420-41-2; 3-(3-Fluoro-5-trifluoromethyl-phenyl)-propionic acid; 3-(3-Fluoro-5-(trifluoromethyl)phenyl)propionic Acid
EINECS	Contact for details

Quality Control

Our production of 3-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Propionic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for cGMP and ISO applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.