Description

1H-Pyrrolo[2,3-B]Pyridine-4-Carboxaldehyde, 1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected heterocyclic aldehyde building block, essential for advanced organic synthesis. Its core value lies in providing a reactive aldehyde functionality while the tris(isopropyl)silyl (TIPS) group offers orthogonal protection for the pyrrole nitrogen, enabling precise, multi-step synthetic sequences. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those containing fused pyrrolopyridine (aza-indole) scaffolds with potential kinase inhibitory activity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require sophisticated heterocyclic cores.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for catalysis, and specialty polymers where the TIPS group aids in solubility and processability.
• Chemical Biology & Probe Development: Employed in the creation of fluorescent tags, molecular probes, and bioconjugation reagents due to its reactive aldehyde handle.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry, enabling studies on new cross-coupling, cyclization, and functional group transformation reactions.
• Scale-up Process Chemistry: The TIPS-protected aldehyde is strategically used in multi-kilogram scale API synthesis where selective deprotection is required at a later stage.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-4-Carboxaldehyde, 1-[Tris(1-Methylethyl)Silyl]-
CAS No.	916259-53-5
Molecular Formula	C17H26N2OSi
Molecular Weight	302.49 g/mol
Synonyms	1-TIPS-1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde; 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde; 4-Formyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde, 1-(triisopropylsilyl)-; 1-Triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde; TIPS-7-azaindole-4-carboxaldehyde; 1-(Triisopropylsilyl)-7-azaindole-4-carbaldehyde
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-4-Carboxaldehyde, 1-[Tris(1-Methylethyl)Silyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All material is characterized by advanced analytical techniques including HPLC, GC, NMR (1H & 13C), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storage under an inert atmosphere (argon or nitrogen) to maintain optimal purity and prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.