Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxaldehyde, 1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected heterocyclic aldehyde building block, essential for advanced organic synthesis. Its core value lies in providing a reactive aldehyde functionality while the tris(isopropyl)silyl (TIPS) group offers robust protection for the pyrrole nitrogen, enabling precise, multi-step synthetic sequences. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a building block for creating functionalized organic semiconductors and advanced polymers with tailored electronic properties.
• Chemical Biology: Employed in the synthesis of molecular probes and labeled compounds for studying biological mechanisms and drug-target interactions.
• Academic & Contract Research: A valuable reagent for methodological development and complex natural product synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxaldehyde, 1-[Tris(1-Methylethyl)Silyl]-
CAS No.	916259-49-9
Molecular Formula	C17H26N2OSi
Molecular Weight	302.49 g/mol
Synonyms	1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxaldehyde; 1-TIPS-7-azaindole-5-carboxaldehyde; 5-Formyl-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; 1-Triisopropylsilyl-7-azaindole-5-carbaldehyde; 1-TIPS-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde; 1-Triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine-5-carboxaldehyde; 5-Carbaldehyde-1-triisopropylsilyl-7-azaindole
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxaldehyde, 1-[Tris(1-Methylethyl)Silyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.