Description

5-Methoxycarbonylthiophene-2-Boronic Acid Pinacol Ester is a high-purity organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex heterocyclic systems. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those containing functionalized thiophene scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific thiophene-based structures.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as conductive polymers and organic semiconductors.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds with aryl or vinyl halides.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a versatile handle for the bioconjugation and labeling of biomolecules in probe development.

Basic Information

Product Name	5-Methoxycarbonylthiophene-2-Boronic Acid Pinacol Ester
CAS No.	916138-13-1
Molecular Formula	C₁₂H₁₇BO₄S
Molecular Weight	268.14 g/mol
Synonyms	2-(Methoxycarbonyl)thiophene-5-boronic acid pinacol ester; Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate; 5-(Methoxycarbonyl)thiophen-2-ylboronic acid pinacol ester; Thiophene-2-carboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 5-(pinacolboryl)thiophene-2-carboxylate; 5-Carbomethoxythiophene-2-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Methoxycarbonylthiophene-2-Boronic Acid Pinacol Ester undergoes rigorous quality testing to ensure compliance with industry standards for fine chemical intermediates. Each batch is analyzed to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other relevant parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.