Description

4-([1,3]Dioxolan-2-Ylmethoxy)-Phenylboronic Acid is a specialized organoboron compound featuring a phenylboronic acid core protected by a dioxolane-functionalized methoxy group. This unique structure makes it a valuable protected boronic acid building block for advanced organic synthesis, particularly in cross-coupling reactions where the acid-sensitive boronic acid moiety requires temporary protection. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing complex molecules, including active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key, protected intermediate for the synthesis of biaryl compounds, a common structural motif in pharmaceuticals and organic electronics.
• Pharmaceutical Intermediate Synthesis: Used in the multi-step synthesis of complex drug candidates, where the protecting group allows for selective reactions elsewhere on the molecule.
• Agrochemical Active Ingredient Development: Employed in creating novel herbicides, fungicides, and insecticides that require specific biphenyl or aryl-heteroaryl structures.
• Material Science & OLED Development: Acts as a precursor for constructing conjugated polymers and small-molecule organic semiconductors used in light-emitting diodes (OLEDs) and other electronic devices.
• Ligand and Catalyst Synthesis: Utilized in the preparation of sophisticated ligands for catalysis or as a building block for metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Can be used to synthesize molecules that interact with biological targets, leveraging the boronic acid group's affinity for diols.

Basic Information

Product Name	4-([1,3]Dioxolan-2-Ylmethoxy)-Phenylboronic Acid
CAS No.	915402-13-0
Molecular Formula	C12H15BO5
Molecular Weight	250.06 g/mol
Synonyms	[4-([1,3]Dioxolan-2-ylmethoxy)phenyl]boronic acid; 4-(1,3-Dioxolan-2-ylmethoxy)benzeneboronic acid; (4-((1,3-Dioxolan-2-yl)methoxy)phenyl)boronic acid; 2-[4-(Borono)phenoxymethyl]-1,3-dioxolane; B-[4-([1,3]Dioxolan-2-ylmethoxy)phenyl]boronic acid; Protected 4-Hydroxyphenylboronic Acid Ester
EINECS	Contact for details

Quality Control

Our 4-([1,3]Dioxolan-2-Ylmethoxy)-Phenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process-scale applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to support customers operating under GMP, ISO, and other regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.