Description

1H-Imidazole-4-Carboxaldehyde, 5-(Trifluoromethyl)- is a high-value trifluoromethylated heterocyclic building block, essential for introducing unique physicochemical properties into target molecules. Its core value lies in enabling the synthesis of advanced materials and bioactive compounds with enhanced metabolic stability, lipophilicity, and binding affinity. This compound is critically needed by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group improves biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized N-heterocyclic carbene (NHC) ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional polymers, metal-organic frameworks (MOFs), and organic electronic materials.
• Chemical Biology Probes: Utilized to develop fluorescent tags and molecular probes for studying biological processes and enzyme activity.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the incorporation of a functionalized imidazole core.

Basic Information

Product Name	1H-Imidazole-4-Carboxaldehyde, 5-(Trifluoromethyl)-
CAS No.	915369-31-2
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	5-(Trifluoromethyl)-1H-imidazole-4-carboxaldehyde; 5-(Trifluoromethyl)-4-imidazolecarboxaldehyde; 4-Formyl-5-(trifluoromethyl)imidazole; 5-Trifluoromethyl-1H-imidazole-4-carbaldehyde; 1H-Imidazole-4-carboxaldehyde, 5-(trifluoromethyl)-; 5-Trifluoromethylimidazole-4-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Carboxaldehyde, 5-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing identity, purity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (argon/nitrogen). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.