Description

4,4-Difluoro-L-Proline Methyl Ester Trifluoroacetate is a high-purity, fluorinated proline derivative salt, a critical building block in modern pharmaceutical research and development. Its core value lies in introducing fluorine atoms into peptide backbones, a strategic modification that can dramatically enhance a drug candidate's metabolic stability, bioavailability, and binding affinity. This compound is essential for medicinal chemists and researchers in the pharmaceutical and biotechnology industries focused on developing novel peptide-based therapeutics, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide drugs and peptidomimetics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the effects of fluorination on peptide conformation and biological activity.
• Protease Inhibitor Development: Serves as a crucial component in the design and synthesis of inhibitors for various enzymes like prolyl oligopeptidase.
• Bioconjugation and Probe Synthesis: Employed in creating fluorinated probes for imaging and diagnostic applications.
• Academic & Institutional R&D: Used in universities and research institutes for advanced studies in organic synthesis and chemical biology.

Basic Information

Product Name	4,4-Difluoro-L-Proline Methyl Ester Trifluoroacetate
CAS No.	915230-14-7
Molecular Formula	C8H10F5NO4
Molecular Weight	279.16 g/mol
Synonyms	(2S)-4,4-Difluoro-1-(methoxycarbonyl)pyrrolidine-2-carboxylic acid; trifluoroacetate L-Proline, 4,4-difluoro-, methyl ester, trifluoroacetate (salt) Methyl (2S)-4,4-difluoro-2-pyrrolidinecarboxylate trifluoroacetate 4,4-Difluoro-L-proline methyl ester TFA salt 4,4-Difluoro-L-proline methyl ester trifluoroacetic acid salt (S)-Methyl 4,4-difluoropyrrolidine-2-carboxylate trifluoroacetate DFP-OMe•TFA
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-L-Proline Methyl Ester Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and chiral purity suitable for demanding research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.