Description

(4,4-Difluorocyclohexyl)Acetic Acid is a versatile fluorinated organic building block of significant interest in advanced chemical synthesis. Its core value lies in the unique properties imparted by the difluorocyclohexyl moiety, which is crucial for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, improving their dielectric anisotropy and thermal stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, lower surface energy, and improved weatherability.
• Chemical Biology & Proteomics: Utilized as a building block for designing chemical probes and activity-based protein profiling (ABPP) agents to study enzyme function.
• Material Science Research: Acts as a precursor for surface modification agents and fluorinated coatings that require specific hydrophobic and oleophobic properties.

Basic Information

Product Name	(4,4-Difluorocyclohexyl)Acetic Acid
CAS No.	915030-40-9
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	2-(4,4-Difluorocyclohexyl)acetic acid; 4,4-Difluorocyclohexaneacetic Acid; (4,4-Difluorocyclohexyl)ethanoic Acid; NSC 781106; 915030-40-9; 4,4-Difluorocyclohexylacetic Acid; trans/cis-(4,4-Difluorocyclohexyl)acetic Acid (mixture)
EINECS	Contact for details

Quality Control

Our (4,4-Difluorocyclohexyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.