Description

Biphenyl-2-Boronic Acid Pinacol Ester is a high-purity organoboron reagent, a key building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex biaryl structures found in advanced materials and pharmaceuticals. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or substituted biphenyl moieties.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex biaryl systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific biphenyl-based architectures.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, liquid crystals, and emissive materials for organic light-emitting diodes (OLEDs) due to its rigid biphenyl core.
• Ligand & Catalyst Preparation: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and other transition metal-catalyzed processes.
• Chemical Research & Development: A valuable tool for academic and industrial R&D labs exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	Biphenyl-2-Boronic Acid Pinacol Ester
CAS No.	914675-52-8
Molecular Formula	C18H21BO2
Molecular Weight	280.17 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; [1,1'-Biphenyl]-2-boronic acid, pinacol ester; Biphenyl-2-ylboronic acid pinacol ester; 2-Biphenylboronic Acid Pinacol Ester; 2-(Biphenyl-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Borono[1,1'-biphenyl] Pinacol Ester
EINECS	Contact for details

Quality Control

Our Biphenyl-2-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for comprehensive characterization and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.