Description

1-tert-Butyloxycarbonylpyrazole-3-Boronic Acid Pinacol Ester is a high-value, protected boronic acid ester building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient, controlled cross-coupling reactions, particularly in the construction of complex heterocyclic scaffolds. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and the protected pyrazole boronate.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of new drug candidates, especially those containing pyrazole-based pharmacophores.
• Agrochemical Active Ingredient Development: Employed in creating novel herbicides, fungicides, and insecticides with pyrazole cores.
• Material Science Research: Serves as a building block for organic electronic materials, ligands for catalysts, and advanced polymers.
• Parallel and Combinatorial Chemistry: Ideal for library synthesis due to its stability and reactivity in solid-phase and solution-phase methodologies.
• Process Chemistry Optimization: Used to develop scalable, efficient routes for the commercial production of target molecules.

Basic Information

Item	Details
Product Name	1-tert-Butyloxycarbonylpyrazole-3-Boronic Acid Pinacol Ester
CAS No.	914672-66-5
Molecular Formula	C15H25BN2O4
Molecular Weight	308.18 g/mol
Synonyms	1-Boc-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(tert-Butoxycarbonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3-Borono-1-(tert-butoxycarbonyl)-1H-pyrazole pinacol ester; 1-Boc-pyrazole-3-boronic acid pinacol ester; Pyrazole-3-boronic acid, 1-(1,1-dimethylethoxy)carbonyl-, 1,1-dimethylethyl ester, pinacol ester; 914672-66-5; Boc-Pyrazole-3-Bpin
EINECS	Contact for details

Quality Control

Every batch of 1-tert-Butyloxycarbonylpyrazole-3-Boronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive coupling reactions. Our quality commitment includes comprehensive analysis via HPLC, NMR (1H, 13C, 11B), and mass spectrometry. A detailed Certificate of Analysis (COA) providing full specification data is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.