Description

(2-Chloro-3-Methyl-5-Trifluoromethoxy-Phenyl)-Acetonitrile is a high-value, multi-functional aromatic nitrile building block designed for advanced chemical synthesis. Its molecular architecture, featuring chloro, methyl, and trifluoromethoxy substituents, makes it a critical intermediate for developing novel active ingredients with enhanced properties. This compound is essential for research and production in the agrochemical and pharmaceutical industries, where it is used to create new generations of crop protection agents and pharmaceutical candidates.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy and chloro groups.
• Pharmaceutical Research: Serves as a versatile building block for constructing complex molecules in medicinal chemistry, particularly for developing candidates targeting central nervous system (CNS) and metabolic diseases.
• Liquid Crystal & OLED Materials: Used in the research and development of advanced electronic materials, where its aromatic core and substituents contribute to desired electronic and steric properties.
• Functional Dye Synthesis: Acts as an intermediate for producing specialized dyes and pigments with unique light-absorption characteristics.
• Cross-Coupling Reactions: The nitrile and halogen groups make it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: Supplied to custom synthesis organizations (CSOs) and R&D departments for proprietary molecule development and scale-up projects.

Basic Information

Product Name	(2-Chloro-3-Methyl-5-Trifluoromethoxy-Phenyl)-Acetonitrile
CAS No.	914637-21-1
Molecular Formula	C10H7ClF3NO
Molecular Weight	249.62 g/mol
Synonyms	2-(2-Chloro-3-methyl-5-(trifluoromethoxy)phenyl)acetonitrile; (2-Chloro-3-methyl-5-(trifluoromethoxy)phenyl)acetonitrile; 2-Chloro-3-methyl-5-(trifluoromethoxy)benzyl cyanide; α-(2-Chloro-3-methyl-5-trifluoromethoxyphenyl)acetonitrile; 914637-21-1; Acetonitrile, (2-chloro-3-methyl-5-(trifluoromethoxy)phenyl)-
EINECS	Contact for details

Quality Control

Our (2-Chloro-3-Methyl-5-Trifluoromethoxy-Phenyl)-Acetonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere after opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.