Description

2-Bromo-3-Methyl-4,4,4-Trifluorobutyric Acid is a specialized fluorinated organic acid building block of significant interest in advanced chemical synthesis. Its molecular structure, featuring both bromine and trifluoromethyl groups, makes it a versatile intermediate for introducing fluorinated motifs, which are critical for modulating the physicochemical properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where fluorination is a key strategy to enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved performance and stability.
• Advanced Polymer Chemistry: Employed to synthesize fluorinated monomers or modifiers for specialty polymers with enhanced chemical resistance and surface properties.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for constructing complex molecules via reactions involving the carboxylic acid and bromine functional groups.

Basic Information

Product Name	2-Bromo-3-Methyl-4,4,4-Trifluorobutyric Acid
CAS No.	914635-99-7
Molecular Formula	C5H6BrF3O2
Molecular Weight	235.00 g/mol
Synonyms	2-Bromo-3-methyl-4,4,4-trifluorobutanoic acid; 4,4,4-Trifluoro-2-bromo-3-methylbutyric acid; 3-Methyl-2-bromo-4,4,4-trifluorobutyric acid; α-Bromo-β-methyl-γ,γ,γ-trifluorobutyric acid; Butyric acid, 2-bromo-3-methyl-4,4,4-trifluoro-; 914635-99-7; (RS)-2-Bromo-3-methyl-4,4,4-trifluorobutyric acid
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Methyl-4,4,4-Trifluorobutyric Acid is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance for critical synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.