Description

4-Bromo-1-Isopropenyloxy-2-Trifluoromethyl-Benzene is a high-value, multi-functional aromatic building block designed for advanced chemical synthesis. Its unique structure, featuring bromine, trifluoromethyl, and isopropenyloxy substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated or halogenated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl and conjugated systems.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) in medicinal and agrochemical chemistry due to its distinct fluorine substitution pattern.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific custom synthesis projects.

Basic Information

Product Name	4-Bromo-1-Isopropenyloxy-2-Trifluoromethyl-Benzene
CAS No.	914635-61-3
Molecular Formula	C10H8BrF3O
Molecular Weight	281.07 g/mol
Synonyms	1-Bromo-4-(isopropenyloxy)-2-(trifluoromethyl)benzene; 2-Trifluoromethyl-4-bromo-1-isopropenyloxybenzene; 4-Bromo-α,α,α-trifluoro-2-isopropenyloxytoluene; Benzene, 4-bromo-1-(1-methylethenyl)oxy-2-(trifluoromethyl)-; 4-Bromo-2-trifluoromethylphenyl isopropenyl ether; 1-Isopropenyloxy-4-bromo-2-trifluoromethylbenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Isopropenyloxy-2-Trifluoromethyl-Benzene is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.