Description

4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)Phenylboronic Acid is a sophisticated boronic acid derivative featuring a spirocyclic acetal-protected amine sulfonyl linker, making it a valuable building block for modern synthetic chemistry. This compound matters for its role in facilitating complex coupling reactions, particularly in the synthesis of pharmaceutical intermediates and advanced materials where precise molecular architecture is critical. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries engaged in Suzuki-Miyaura cross-coupling and other palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl motifs found in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific boronic acid coupling steps.
• Material Science & OLED Development: Serves as a building block for creating organic electronic materials, including charge-transport layers and emissive materials in OLED devices.
• Ligand & Catalyst Design: The unique spirocyclic structure can be utilized to develop novel ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Proteolysis-Targeting Chimeras (PROTACs): Employed in the synthesis of linker components for these targeted protein degradation therapeutics.
• Chemical Biology & Bioconjugation: Useful for modifying biomolecules or creating chemical probes due to the reactivity of the boronic acid group.

Basic Information

Product Name	4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)Phenylboronic Acid
CAS No.	914610-70-1
Molecular Formula	C17H24BNO6S
Molecular Weight	381.25 g/mol
Synonyms	[4-(1,4-Dioxa-8-azaspiro[4.5]decane-8-sulfonyl)phenyl]boronic acid; 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-ylsulfonyl)benzeneboronic acid; 4-(8-Sulfonyl-1,4-dioxa-8-azaspiro[4.5]decan)phenylboronic acid; B-[4-[(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)sulfonyl]phenyl]boronic acid; CAS 914610-70-1; 4-(1,4-Dioxa-8-azaspiro[4.5]decan-8-sulfonyl)phenylboronic acid pinacol ester (related protected form)
EINECS	Contact for details

Quality Control

Our 4-(1,4-Dioxa-8-Azaspiro[4.5]Decan-8-Ylsulfonyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.