Description

4-Morpholinesulfonamide, n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is a high-value, multi-functional organic building block that combines a sulfonamide pharmacophore with a boronic ester pinacol group. This unique structure makes it a critical intermediate for the synthesis of complex molecules in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: The boronic ester moiety serves as a crucial coupling partner for creating biaryl and heterobiaryl structures central to modern medicinal chemistry.
• Protease Inhibitor Research: The morpholinesulfonamide group is a common motif in the development of enzyme inhibitors.
• Agrochemical Synthesis: Intermediate for creating novel active ingredients with enhanced efficacy and selectivity.
• Material Science: Used in the research and development of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	4-Morpholinesulfonamide, n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-
CAS No.	914606-94-3
Molecular Formula	C16H25BN2O4S
Molecular Weight	352.26 g/mol
Synonyms	N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine-4-sulfonamide; 4-Morpholinesulfonamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-(N-Morpholinosulfonyl)aniline-4-boronic acid pinacol ester; 4-(Morpholine-4-sulfonamido)phenylboronic acid pinacol ester; B-[4-[(Morpholine-4-sulfonyl)amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 4-Morpholinesulfonamide, n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]- is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity (typically >95% by HPLC), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis of the boronic ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.