Description

4-(Cbz-Aminomethyl)Phenyboronic Acid is a high-purity, bifunctional organic building block that combines a boronic acid group with a carboxybenzyl (Cbz)-protected amine. This compound is essential for facilitating complex cross-coupling reactions, such as the Suzuki-Miyaura reaction, while offering orthogonal protection for subsequent synthetic modifications. It is a critical intermediate for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced materials science who require precise molecular construction and reliable coupling efficiency.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in oncology and CNS research.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid reagent for forming carbon-carbon bonds in complex molecule assembly.
• Peptidomimetics & PROTACs: Used in the construction of peptide mimics and proteolysis-targeting chimeras (PROTACs) due to its protected amine functionality.
• Agrochemical Synthesis: Intermediate in creating advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Ligand & Catalyst Development: Precursor for synthesizing specialized ligands and organometallic catalysts.
• Material Science: Building block for organic electronic materials, such as those used in OLEDs and conductive polymers.
• Bioconjugation: Useful in developing linker molecules for antibody-drug conjugates (ADCs) and other bioconjugation strategies.

Basic Information

Product Name	4-(Cbz-Aminomethyl)Phenyboronic Acid
CAS No.	914452-61-2
Molecular Formula	C15H16BNO4
Molecular Weight	285.11 g/mol
Synonyms	[4-[[(Phenylmethoxy)carbonylamino]methyl]phenyl]boronic acid; N-[(4-Boronophenyl)methyl]carbamic acid benzyl ester; 4-(N-Cbz-Aminomethyl)benzeneboronic acid; Cbz-NH-CH2-PhB(OH)2; 4-(Carbobenzyloxyaminomethyl)phenylboronic acid; Benzyl N-[(4-boronophenyl)methyl]carbamate; 4-(Aminomethyl)phenylboronic acid Cbz-protected
EINECS	Contact for details

Quality Control

Our 4-(Cbz-Aminomethyl)Phenyboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.