Description

2-Fluoro-2-Phenyl-Cyclopropanecarboxylic Acid is a high-value, synthetically versatile fluorinated cyclopropane derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, prized for its unique three-membered ring structure and fluorine atom, which can dramatically influence the biological activity and physicochemical properties of target molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorinated cyclopropane motifs into new molecular entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Research: Used in developing new-generation herbicides, fungicides, and insecticides where the fluorocyclopropane unit enhances stability, bioavailability, and target specificity.
• Ligand & Catalyst Development: Employed in the construction of chiral ligands and organocatalysts for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science: Serves as a monomer or functional additive in the research of specialty polymers and advanced materials with tailored optical or electronic properties.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme mechanisms and protein-ligand interactions due to the fluorine atom's utility as an NMR and metabolic stability marker.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards for clinical trial material production.

Basic Information

Product Name	2-Fluoro-2-Phenyl-Cyclopropanecarboxylic Acid
CAS No.	914221-42-4
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	2-Fluoro-2-phenylcyclopropane-1-carboxylic acid; 2-Phenyl-2-fluorocyclopropanecarboxylic acid; 1-Carboxy-2-fluoro-2-phenylcyclopropane; (1R,2S)-rel-2-Fluoro-2-phenylcyclopropanecarboxylic acid; (1S,2R)-rel-2-Fluoro-2-phenylcyclopropanecarboxylic acid; 2-Fluoro-2-phenyl-1-cyclopropanecarboxylic acid; NSC 796078
EINECS	Contact for details

Quality Control

Our 2-Fluoro-2-Phenyl-Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical specifications such as assay, enantiomeric excess (if applicable), and impurity profiles. Our quality commitment supports applications requiring material traceability and compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.