Description

Methyl 3-Amino-2-(Trifluoromethyl)Propionate is a high-value trifluoromethylated amino acid ester building block, prized for its ability to introduce both fluorine and amine functionalities into complex molecular architectures. This compound is essential for medicinal chemistry and agrochemical research, enabling the synthesis of novel compounds with enhanced metabolic stability, bioavailability, and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics where the trifluoromethyl group modulates biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms for improved environmental stability and efficacy.
• Peptidomimetics & Bioactive Molecules: Serves as a constrained, fluorinated amino acid analog for designing novel peptides and protein ligands with tailored properties.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials that benefit from fluorine's unique electronic characteristics.
• Chemical Biology Probes: Acts as a building block for creating fluorescent tags, enzyme substrates, and other molecular probes used in diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	Methyl 3-Amino-2-(Trifluoromethyl)Propionate
CAS No.	914203-47-7
Molecular Formula	C6H10F3NO2
Molecular Weight	185.15 g/mol
Synonyms	Methyl 3-amino-2-(trifluoromethyl)propanoate; 3-Amino-2-(trifluoromethyl)propionic acid methyl ester; 2-(Trifluoromethyl)-β-alanine methyl ester; Methyl β-amino-β-trifluoromethylpropionate; 3-Amino-2-trifluoromethyl-propionic acid methyl ester; (3-Amino-2-(trifluoromethyl)propyl) methyl ester; Methyl 3-amino-2-(trifluoromethyl)propanoate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards for research and development. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.