Description

2,3-Difluoro-1-Iodo-4-Methylbenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring iodine and fluorine substituents on a methylbenzene core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring difluorinated and iodinated aromatic motifs.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and metabolic stability.
• Material Science: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling rapid molecular diversification.
• Chemical Synthesis & Process Development: Employed in medicinal chemistry for lead optimization and in scaling up synthetic routes for target compounds.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2,3-Difluoro-1-Iodo-4-Methylbenzene
CAS No.	914100-41-7
Molecular Formula	C7H5F2I
Molecular Weight	253.92 g/mol
Synonyms	1-Iodo-2,3-difluoro-4-methylbenzene; 2,3-Difluoro-4-methyl-1-iodobenzene; 4-Methyl-2,3-difluoro-1-iodobenzene; 2,3-Difluoro-4-methylphenyl iodide; 1-Iodo-4-methyl-2,3-difluorobenzene; 2,3-Difluoro-1-iodo-p-xylene (informal); 914100-41-7 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-1-Iodo-4-Methylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.