Description

5-(tert-Butylcarbamoyl)Pyridine-3-Boronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyridine and biaryl motifs for oncology, CNS, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings, essential for creating complex molecular architectures in drug discovery and development.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in OLED devices.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Employed as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: A critical reagent for methodological development and synthetic chemistry research in university and CRO laboratories.

Basic Information

Product Name	5-(tert-Butylcarbamoyl)Pyridine-3-Boronic Acid
CAS No.	913835-99-1
Molecular Formula	C10H15BN2O3
Molecular Weight	222.06 g/mol
Synonyms	5-[(tert-Butylamino)carbonyl]-3-pyridineboronic acid; 3-Pyridineboronic acid, 5-[[(1,1-dimethylethyl)amino]carbonyl]-; 5-(tert-Butylcarbamoyl)pyridine-3-boronic acid pinacol ester (common precursor); 5-(N-tert-Butylcarbamoyl)-3-pyridylboronic acid; 913835-99-1; tert-Butyl 5-borono-3-pyridinecarboxylate (related structure); B-[5-[(tert-Butylcarbamoyl)]-3-pyridyl]boronic acid
EINECS	Contact for details

Quality Control

Every batch of 5-(tert-Butylcarbamoyl)Pyridine-3-Boronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), boronic acid content, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for critical research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) for long-term storage to maintain stability and purity. Handle and open containers in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Boronic Acid Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.