Description

1H-Indole-1-Carboxylic Acid, 2-Borono-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated, multi-functional organoboron building block designed for advanced synthetic chemistry. This compound matters because it integrates a protected boronic acid moiety with a silyl-protected phenol and a tert-butyl ester, offering exceptional versatility and stability for complex coupling reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, particularly in constructing challenging heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing coupling partner for constructing biaryl and heterobiaryl structures under mild conditions.
• Agrochemical Research: Used in the development of new herbicides and fungicides that require specific indole core structures.
• Material Science: Employed in the creation of organic electronic materials and advanced polymers where precise molecular architecture is required.
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds and probes for studying biological pathways and protein interactions.
• Process Chemistry & Scale-up: Provides a stable, handleable intermediate for optimizing and scaling synthetic routes from lab to pilot plant.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-78-0
Molecular Formula	C20H32BNO4Si
Molecular Weight	389.37 g/mol
Synonyms	2-Borono-4-[(tert-butyldimethylsilyl)oxy]-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; 4-[(Tert-Butyldimethylsilyl)oxy]-2-borono-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-borono-4-((tert-butyldimethylsilyl)oxy)-1H-indole-1-carboxylate; Boronic acid, B-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(1,1-dimethylethoxy)carbonyl]-1H-indol-2-yl]-; TBDMS-protected boronic acid indole ester; 913388-78-0
EINECS	Contact for details

Quality Control

Every batch of our 1H-Indole-1-Carboxylic Acid, 2-Borono-4-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-, 1-(1,1-Dimethylethyl) Ester undergoes rigorous analytical testing to ensure identity, purity, and consistency for sensitive synthetic applications. We adhere to strict in-house specifications aligned with cGMP principles for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), residual solvents, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.