Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-[2-(1-Piperidinyl)Ethoxy]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid ester derivative of indole, designed as a key intermediate for advanced pharmaceutical research and development. This compound matters for its role in modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, which is fundamental for constructing complex bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries working on novel drug candidates and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling Reagent: Utilized as a versatile boronate ester partner for forming carbon-carbon bonds in complex molecule assembly.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the development of new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides.
• Material Science Precursor: Potential intermediate in the development of organic electronic materials and functional polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process scale-up.

Basic Information

Item	Details
Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-[2-(1-Piperidinyl)Ethoxy]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-68-8
Molecular Formula	C20H29BN2O4
Molecular Weight	372.27 g/mol
Synonyms	2-Borono-5-[2-(1-piperidinyl)ethoxy]-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 2-borono-5-(2-(piperidin-1-yl)ethoxy)-1H-indole-1-carboxylate; 5-[2-(Piperidin-1-yl)ethoxy]-1H-indole-2-boronic acid tert-butyl ester; Boronic acid, B-[5-[2-(1-piperidinyl)ethoxy]-1H-indol-2-yl]-, 1,1-dimethylethyl ester; 913388-68-8; tert-Butyl 5-(2-(piperidin-1-yl)ethoxy)-2-boronoindole-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Carboxylic Acid, 2-Borono-5-[2-(1-Piperidinyl)Ethoxy]-, 1-(1,1-Dimethylethyl) Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical R&D and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.