Description

1H-Indole-1-Carboxylic Acid, 2-Borono-6-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Carbonyl]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid ester derivative of indole, designed as a key building block for advanced organic synthesis. This compound is critical for medicinal chemistry research, particularly in the development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, especially for creating targeted covalent inhibitors and protease inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting proteases and other enzymes.
• Medicinal Chemistry Research: Used as a versatile building block for constructing complex molecular scaffolds in drug discovery programs.
• Covalent Inhibitor Development: The boronic acid ester functionality makes it valuable for designing targeted covalent inhibitors that form stable complexes with active site residues.
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Organic Synthesis: Acts as a specialized reagent for Suzuki-Miyaura cross-coupling reactions and other palladium-catalyzed transformations.
• Peptidomimetic Synthesis: Used in the creation of peptidomimetics and macrocyclic compounds for enhanced biological activity and stability.

Basic Information

Item	Details
Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-6-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Carbonyl]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-59-7
Molecular Formula	C25H34BN3O7
Molecular Weight	499.37 g/mol
Synonyms	tert-Butyl 2-borono-6-[(4-(tert-butoxycarbonyl)piperazine-1-carbonyl)]-1H-indole-1-carboxylate; 1-(tert-Butyl) 1H-indole-1-carboxylate, 2-borono-6-[[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]carbonyl]-; BOC-Piperazine-Indole-Boronic Acid Ester; 913388-59-7; (1-(tert-Butoxycarbonyl)-6-(4-(tert-butoxycarbonyl)piperazine-1-carbonyl)-1H-indol-2-yl)boronic acid
EINECS	Contact for details

Quality Control

Our 1H-Indole-1-Carboxylic Acid, 2-Borono-6-[[4-[(1,1-Dimethylethoxy)Carbonyl]-1-Piperazinyl]Carbonyl]-, 1-(1,1-Dimethylethyl) Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its sensitivity to moisture and oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.