Description

1H-Indole-1,5-Dicarboxylic Acid, 2-Borono-, 1-(1,1-Dimethylethyl) Ester is a high-value, multifunctional boron-containing indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both carboxylic acid ester and boronic acid functionalities, makes it a versatile building block for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry, cross-coupling reactions, and the synthesis of novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid moiety acts as a crucial coupling partner for forming carbon-carbon bonds, essential for constructing biaryl and complex aromatic systems.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Potential precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated indole core.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	1H-Indole-1,5-Dicarboxylic Acid, 2-Borono-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-58-6
Molecular Formula	C15H18BNO6
Molecular Weight	319.12 g/mol
Synonyms	2-Borono-1H-indole-1,5-dicarboxylic acid 1-(1,1-dimethylethyl) ester; 1-tert-Butyl 2-boronoindole-1,5-dicarboxylate; 1-(tert-Butoxycarbonyl)-2-boronoindole-5-carboxylic acid; 5-Carboxy-1H-indole-1-carboxylic acid tert-butyl ester 2-boronic acid; Boronic acid, B-[1-[(1,1-dimethylethoxy)carbonyl]-1H-indol-5-yl]-; tert-Butyl 2-borono-1H-indole-1,5-dicarboxylate
EINECS	Contact for details

Quality Control

Our 1H-Indole-1,5-Dicarboxylic Acid, 2-Borono-, 1-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability, consistency, and reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.