Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-[(4-Methyl-1-Piperazinyl)Carbonyl]-, 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid ester derivative of indole, designed as a key pharmaceutical intermediate and building block for advanced organic synthesis. Its molecular architecture, featuring both a boronate ester and a piperazine carboxamide moiety, makes it a versatile precursor for Suzuki-Miyaura cross-coupling reactions in drug discovery. This high-purity compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile organoboron partner for forming carbon-carbon bonds in medicinal chemistry and materials science research.
• Protease Inhibitor Research: Used in the development of enzyme inhibitors, leveraging the indole and piperazine scaffolds for targeted molecular interactions.
• Chemical Biology Probes: Employed in the creation of labeled compounds and probes for studying biological pathways and protein functions.
• Advanced Material Synthesis: A precursor for functionalized organic molecules used in organic electronics and specialty polymers.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-[(4-Methyl-1-Piperazinyl)Carbonyl]-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-57-5
Molecular Formula	C20H28BN3O4
Molecular Weight	385.27 g/mol
Synonyms	tert-Butyl 2-borono-5-[(4-methylpiperazine-1-carbonyl)]-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-2-borono-5-[(4-methylpiperazine-1-carbonyl)]indole; 2-Boronotert-butyl 5-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole-1-carboxylate; BOC-2-Boronoindole-5-carboxamide piperazine derivative; 913388-57-5; (1-(tert-Butoxycarbonyl)-5-((4-methylpiperazine-1-carbonyl))-1H-indol-2-yl)boronic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.