Description

1H-Indole-1-Carboxylic Acid, 2-Borono-5-(1-Piperidinylmethyl)-, 1-(1,1-Dimethylethyl) Ester is a sophisticated boronic acid ester derivative of indole, designed for advanced synthetic applications. This compound is a critical building block in modern pharmaceutical research and development, enabling precise molecular construction. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronate ester coupling partner for constructing biaryl and heterobiaryl systems common in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential new drugs under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Facilitates the creation of labeled compounds and probes for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-5-(1-Piperidinylmethyl)-, 1-(1,1-Dimethylethyl) Ester
CAS No.	913388-56-4
Molecular Formula	C20H29BN2O4
Molecular Weight	372.27 g/mol
Synonyms	2-Borono-5-(piperidin-1-ylmethyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-borono-5-(piperidin-1-ylmethyl)-1H-indole-1-carboxylate; 5-(Piperidin-1-ylmethyl)-1H-indole-2-boronic acid 1-tert-butoxycarbonyl derivative; BOC-Protected 5-(Piperidin-1-ylmethyl)indole-2-boronic acid pinacol ester analog; 913388-56-4; 1-(tert-Butoxycarbonyl)-5-(piperidin-1-ylmethyl)indole-2-boronic acid ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.