Description

3-Fluoro-4-(Trifluoromethoxy)Phenylacetylen is a high-value fluorinated aromatic alkyne building block, essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, is critical for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery, particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine motifs enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe Development: Employed in click chemistry and bioorthogonal labeling strategies to create fluorescent tags or affinity probes for studying biological systems.
• Catalyst Ligand Synthesis: Useful for preparing novel ligand frameworks in catalysis research, potentially improving selectivity and efficiency in coupling reactions.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethoxy)Phenylacetylen
CAS No.	912617-68-6
Molecular Formula	C9H4F4O
Molecular Weight	204.12 g/mol
Synonyms	3-Fluoro-4-(trifluoromethoxy)phenylacetylene; 1-Ethynyl-3-fluoro-4-(trifluoromethoxy)benzene; 3-Fluoro-4-(trifluoromethoxy)ethynylbenzene; 4-Ethynyl-2-fluoro-1-(trifluoromethoxy)benzene; 2-Fluoro-α-(trifluoromethoxy)phenylacetylene; [3-Fluoro-4-(trifluoromethoxy)phenyl]acetylene
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-(Trifluoromethoxy)Phenylacetylen adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; containers must be kept sealed and handled under inert conditions to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.