Description

2-Hydroxy-4,4,4-Trifluorobutyronitrile is a versatile fluorinated nitrile building block characterized by its trifluoromethyl and hydroxyl functional groups. This compound is valued for its unique reactivity, serving as a critical intermediate in the synthesis of complex, high-value molecules, particularly in the pharmaceutical and agrochemical sectors. It is essential for researchers and manufacturers developing active ingredients, advanced materials, and fine chemicals who require reliable, high-purity fluorinated synthons.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of trifluoromethyl-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and stability.
• Material Science: Serves as a monomer or precursor for specialty polymers and coatings with tailored surface properties and chemical resistance.
• Liquid Crystal & OLED Materials: A valuable intermediate in the manufacture of fluorinated components for electronic displays and optoelectronic devices.
• Fine Chemical Synthesis: Employed in organic synthesis for constructing complex molecules in medicinal chemistry and chemical biology research.
• Fluorine Chemistry Research: A crucial reagent for exploring new methodologies and reactions in organofluorine chemistry.

Basic Information

Item	Details
Product Name	2-Hydroxy-4,4,4-Trifluorobutyronitrile
CAS No.	912578-73-5
Molecular Formula	C₄H₄F₃NO
Molecular Weight	139.08 g/mol
Synonyms	4,4,4-Trifluoro-3-hydroxybutyronitrile; 3-Hydroxy-4,4,4-trifluorobutyronitrile; 4,4,4-Trifluoro-3-hydroxybutanenitrile; 2-Hydroxy-4,4,4-trifluorobutanenitrile; α-Hydroxy-γ,γ,γ-trifluorobutyronitrile; TFHBN (abbreviation); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4,4,4-Trifluorobutyronitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	≤ 2.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.