Description

6-Chloroindole-2-Boronic Acid, Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-couplings for synthesizing indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used to create novel heterocyclic compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science: Building block for organic electronic materials, such as OLEDs and semiconductors, where the indole core contributes to charge transport properties.
• Chemical Biology: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways.
• Academic & Process R&D: A versatile reagent for methodological development and scaling up synthetic routes in laboratory and pilot plant settings.

Basic Information

Product Name	6-Chloroindole-2-Boronic Acid, Pinacol Ester
CAS No.	912331-84-1
Molecular Formula	C14H17BClNO2
Molecular Weight	277.55 g/mol
Synonyms	6-Chloro-1H-indole-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-chloro-1H-indole; 6-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 6-Chloroindole-2-boronic acid pinacol ester; 6-Chloro-1H-indole-2-boronic acid, pinacol cyclic ester; B-(6-Chloro-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 6-Chloroindole-2-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.